XRCC1 and ADPRT Polymorphisms and Risk of Noncardia Gastric Cancer in Chinese

Gastric cancer (GC) is the sixth most commonly diagnosed malignancy and the third leading cause of cancer deaths worldwide (Ferlay et al., 2010). The highest incidence rates are noted in Japan, Eastern Asia, Andean regions of South America and Eastern Europe, whereas the lowest are observed in North and East Africa, Northern Europe and North America (Ferlay et al., 2010). Incidence rates for GC have declined steadily in several western countries, and similar declining trends have been witnessed only in more recent years in countries with historically high GC incidence including Japan, China, Korea, Columbia, Ecuador, Ukraine, and Russia (Bertuccio et al., 2009). However, while the incidence of noncardia GC has declined in most countries, the rates of cardia GC has remained stable, or have risen in several European countries, Japan and North America (Gonzalez et al., 2012). In China, GC is one of the most common